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目的:通过系统评价及Meta分析,评价黄芩类制剂局部应用辅助牙周基础治疗对慢性牙周炎的临床疗效。方法:检索Pubmed、Cochrane Library、Web of Knowledge、CNKI、CBM数据库,查找黄芩制剂辅助牙周基础治疗局部应用于慢性牙周炎的随机对照实验。资料提取和质量评价后,选取空白对照研究,对探诊深度、临床附着丧失的改变按照用药方法的不同分亚组进行Meta定量分析,对其他临床指标进行系统评价。结果:共9篇文章、652例受试者纳入本研究。结果显示:黄芩类制剂的局部辅助治疗慢性牙周炎,在降低探诊深度[MD=-1.49,95%CI(-2.15,-0.38),P<0.00001],改善牙龈出血及细菌学指标方面,疗效优于单纯基础治疗,未出现明显临床不适;对于附着丧失的改善,有待观察[MD=-0.32,95%CI(-1.01,0.38),P=0.03]。结论:黄芩类制剂局部辅助慢性牙周炎的治疗,是有效的手段。
OBJECTIVE: To evaluate the clinical efficacy of topical application of Scutellaria baicalensis Georgi in the treatment of chronic periodontitis by systematic evaluation and meta-analysis. Methods: The Pubmed, Cochrane Library, Web of Knowledge, CNKI and CBM databases were searched and searched for a randomized controlled trial of Radix Scutellariae for the periodontal treatment of chronic periodontitis. Data extraction and quality evaluation, select the blank control study, the depth of exploration, changes in clinical attachment loss in accordance with the method of sub-sub-group for Meta quantitative analysis of other clinical indicators of systematic evaluation. Results: A total of 9 articles, 652 subjects were included in this study. The results showed that: Scutellariae topical adjuvant treatment of chronic periodontitis, reduce the depth of exploration [MD = -1.49, 95% CI (-2.15, -0.38, P <0.00001], to improve bleeding and bacterial indicators of gingival bleeding , The curative effect is superior to simple basic treatment, no obvious clinical discomfort; for the improvement of adhesion loss, remains to be seen [MD = -0.32,95% CI (-1.01,0.38), P = 0.03]. Conclusion: Radix Scutellariae locally assisted in the treatment of chronic periodontitis is an effective means.