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采用共沉淀法制备芦丁β-环糊精聚合物(β-CDP)载药微球,以L9(34)正交试验设计通过回归分析法对制备工艺进行了优化;分别用激光粒度分布仪、红外光谱仪、综合热分析仪和X射线衍射仪对芦丁β-CDP载药微球进行表征。结果表明:最佳制备工艺条件是β-CDP微球1 g、芦丁0.03 g、蒸馏水60 mL、反应时间3 h、温度60℃;影响因素的大小依次为:芦丁的浓度>β-CDP微球与芦丁投料比>载药时间>载药温度;按优化工艺参数制得的载药微球的总载药量为2.45%,包封率为81.67%;鉴别试验结果表明已形成包合物。
Preparation of β-cyclodextrin polymer (β-CDP) loaded microspheres by coprecipitation method was optimized by L9 (34) orthogonal design method through regression analysis. The microspheres were characterized by laser particle size distribution , Infrared spectrometer, integrated thermal analyzer and X-ray diffractometer were used to characterize the drug-loaded microspheres of rutin β-CDP. The results showed that the optimal preparation conditions were as follows: 1 g β-CDP microspheres, 0.03 g rutin, 60 mL distilled water, reaction time 3 h and temperature 60 ℃. The influencing factors were as follows: concentration of rutin> β-CDP The loading ratio of microspheres to rutin> loading time> drug loading temperature; the total drug load of microspheres prepared by optimizing the process parameters was 2.45%, and the entrapment efficiency was 81.67% Compound.