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目的:探讨血浆白细胞介素(IL)-10,IL-17,IL-18和C反应蛋白(CRP)在冠心病发病过程中的作用及其临床意义。方法:采用酶联免疫双抗体夹心法(ELISA)对160例冠心病患者(急性心肌梗死50例,不稳定型心绞痛68例,稳定型心绞痛42例)和40例正常人血浆中IL-10,IL-17,IL-18和CRP的水平进行检测。结果:冠心病患者血浆IL-10,IL-17,IL-18和CRP的水平均显著高于正常对照组(P<0.05)。结论:IL-10作为冠心病的保护因子,不足以阻止其发生、发展,IL-17,IL-18和CRP的水平与冠心病的发生与发展相关,其水平的检测对冠心病诊断及病情判断有重要意义。
Objective: To investigate the role and clinical significance of plasma interleukin (IL) -10, IL-17, IL-18 and C-reactive protein (CRP) in the pathogenesis of coronary heart disease. Methods: The plasma level of IL-10 in 160 patients with coronary heart disease (50 with acute myocardial infarction, 68 with unstable angina and 42 with stable angina pectoris) and 40 normal controls were detected by enzyme-linked immunosorbent assay (ELISA) IL-17, IL-18 and CRP levels were detected. Results: The levels of plasma IL-10, IL-17, IL-18 and CRP in patients with coronary heart disease were significantly higher than those in the normal control group (P <0.05). Conclusion: IL-10 as a protective factor of coronary heart disease is not enough to prevent the occurrence and development of IL-10, IL-17, IL-18 and CRP levels associated with the occurrence and development of coronary heart disease, the level of detection of coronary heart disease diagnosis and disease Judgment is important.