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OBJECTIVE To retrospectively analyze clinical data of patientsfrom our hospital who underwent radical surgery for esophagealcarcinoma and for adenocarcinoma of the gastric cardia,as well asto investigate prognostic factors affecting the long-term survival ofthe patients.METHODS Data from the patients eligible for our study,admitted to the 4th Hospital of Hebei Medical University fromJanuary 1996 to December 2004,were randomized,and 12distinctive clinicopathologic factors influencing the survival rateof those who underwent radical surgery for esophageal carcinomaor carcinoma of the gastric cardia were collected.Univariate andmultivariate analysis of these individual variables were performedusing the Cox proportional hazard model.RESULTS It was shown by univariate analysis that age,tumorsize,pathologic type,lymph node status,TNM staging,depthof infiltration and encroachment into local organs,etc.,were thefactors that markedly influenced the prognosis of patients(P<0.01).Multivariate analysis showed that pathologic type,numberof the lymph node metastases,involvement of local organs,andTNM staging were independent prognostic factors(P<0.05).CONCLUSION The independent factors influencing theprognosis of patients with esophageal cancer and carcinoma ofthe gastric cardia include pathologic type,number of lymph nodemetastases,involvement of local organs and TNM staging.Themain prognostic factors affecting the patient’s survival are patientage,tumor size and depth of infiltration.In addition,patients withinvolvement of the local organs have a worse prognosis,and theyshould be closely followed up.
OBJECTIVE To retrospectively analyze clinical data of patients from our hospital who underwent radical surgery for esophagealcarcinoma and for adenocarcinoma of the gastric cardia, as well asto investigate prognostic factors affecting the long-term survival of the patients. METHHODS Data from the patients eligible for our study, admitted to the 4th Hospital of Hebei Medical University from January 1996 to December 2004, were randomized, and 12 time-active clinicopathologic factors influencing the survival rate of those who underwent radical surgery for esophageal carcinoma of carcinoma of the gastric cardia were collected. Univariate and multivariate analysis of these individual variables were performedusing the Cox proportional hazard model. RESULTS It was shown by univariate analysis that age, tumorsize, pathologic type, lymph node status, TNM staging, depth of infiltration and encroachment into local organs, etc., were thefactors that markedly influenced the prognosis of patients (P <0.01) .Multivariate anal ysis showed that pathologic type, numberof the lymph node metastases, involvement of local organs, andTNM staging were independent prognostic factors (P <0.05) .CONCLUSION The independent factors influencing the prognosis of patients with esophageal cancer and carcinoma of the gastric cardia include pathologic type, number of lymph node metastases, involvement of local organs and TNM staging. main prognostic factors affecting the patient’s survival are patientage, tumor size and depth of infiltration. addition, patients withinvolvement of the localities have a worse prognosis, and the same can be followed then up.