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目的:评价中国农村地区未经抗癫癎药物(AEDs)治疗的全身强直-阵挛发作(GTCS)癫癎患者的认知功能的状况。方法:采用数字广度测验、言语流畅性测验、听觉词语测验及数字划消测验对144例GTCS患者和144名健康对照者进行认知功能评定。结果:GTCS患者的注意力及计算能力较差,并有瞬间语言记忆、自发的语言运动能力、思维组织能力及干扰抑制能力的下降。结论:未经AEDs治疗的GTCS患者存在广泛的认知功能障碍。AEDs的非规范使用是认知功能损害的主要影响因素。
PURPOSE: To evaluate the cognitive function of patients with generalized tonic-clonic seizures (GTCS) epilepsy who are not treated with anti-epileptic drugs (AEDs) in rural areas of China. Methods: The cognitive function of 144 GTCS patients and 144 healthy controls were evaluated by digital breadth test, verbal fluency test, auditory word test and digital test. Results: Patients with GTCS had poor attention and calculation ability, instantaneous memory, spontaneous motor ability, ability of thinking and suppression of interference. Conclusion: There is a wide range of cognitive dysfunction in GTCS patients who have not been treated with AEDs. Non-canonical use of AEDs is a major contributor to cognitive impairment.