论文部分内容阅读
在有机化学课程中,总要讲到安息香缩合反应,而这一经典的反应,由于要用到氰化物催化,故很难设想将这一实验安排到基础有机化学实验中。自从1943年,Ugai.T.等人发现了V_(B_1)及其许多噻唑类化合物能催化合成安息香以来,使得安息香这一合成实验安排到基础实验中成为可能。 1958年,R.Breslow提出了反应的机理,V_(B_1)很容易失去噻唑环上2-位质子形成稳定的两性离子。
In the course of organic chemistry, there is always talk about benzoin condensation reactions, and this classic response, due to the use of cyanide catalysis, makes it difficult to envision this experiment in basic organic chemistry experiments. Since 1943, when Ugai.T. et al. Found that V_ (B_1) and many of its thiazoles catalyze the synthesis of benzoin, it is possible to make the synthesis of benzoin into the basic experiment. In 1958, R. Breslow proposed the reaction mechanism, V_ (B_1) is easy to lose the 2-position proton on the thiazole ring to form stable zwitterion.