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目的探究和分析鼠神经生长因子(金路捷)对新生儿缺氧缺血性脑病的临床效果和疗效分析,探讨其对新生儿缺氧缺血性脑病的治疗保护作用。方法选择原阳县红十字医院2010年12月至2012年12月收治的患有缺氧缺血性脑病的新生儿,共收集中、重度缺氧缺血性脑病患儿32例,将患者随机分为观察组和对照组,对照组患儿采用“三支持三对症”及胞二磷胆碱治疗,观察组患儿采用“三支持三对症”及鼠神经生长因子治疗,在出生后第4天给予鼠神经生长因子20μɡ,静脉点滴,每天1次,根据临床分度,其中中度10~14 d,重度21~28 d为1个疗程。1个疗程后,观察比较两组患儿的临床表现和新生儿行为神经测定(NANB)评分。结果比较两组患儿临床症状,观察组患儿临床表现明显好转,临床症状基本消失,观察组临床症状改善程度明显优于对照组,差异有统计学意义(P<0.05),比较患者治疗前后的NANB评分,观察组NANB评分明显高于对照组患儿,差异有统计学意义(P<0.05);在治疗效果方面,观察组在显效率和总有效率方面均显著高于对照组,且差异有统计学意义(P<0.05)。结论鼠神经生长因子对新生儿缺氧缺血性脑病的治疗具有较好的保护作用,能有效治疗和改善新生儿缺氧缺血性脑病的临床症状,有效地降低了缺血缺氧性脑病患儿神经系统后遗症的发生率,值得临床推广应用。
Objective To investigate and analyze the clinical effect and therapeutic effect of rat glial growth factor (JN) on neonatal hypoxic-ischemic encephalopathy and to explore its therapeutic and protective effects on neonatal hypoxic-ischemic encephalopathy. Methods 32 neonates with hypoxic-ischemic encephalopathy admitted to the Red Cross Hospital of Yuanyang County from December 2010 to December 2012 were enrolled. A total of 32 children with moderate and severe hypoxic-ischemic encephalopathy were collected and randomized Divided into observation group and control group, the control group of children with “three support three symptomatic ” and citicoline treatment, the observation group of children with “three support three symptomatic ” and mouse nerve growth factor treatment, in On the fourth day after birth, rats were given 20 μ ng of nerve growth factor, intravenously once a day. According to the clinical index, moderate 10 ~ 14 d and severe 21 ~ 28 d were a course of treatment. After a course of treatment, clinical manifestations and neonatal behavioral neurological assessment (NANB) scores were compared between the two groups. Results Compared with the clinical symptoms in both groups, the clinical manifestations of the observation group improved significantly and the clinical symptoms disappeared. The improvement of the clinical symptoms in the observation group was significantly better than that in the control group (P <0.05). Before and after treatment (P <0.05). The NANB score of the observation group was significantly higher than that of the control group (P <0.05). In the treatment effect, the observation group was significantly higher than the control group in both the markedly effective rate and the total effective rate The difference was statistically significant (P <0.05). Conclusion NGF can protect neonatal hypoxic-ischemic encephalopathy effectively and can effectively treat and improve the clinical symptoms of neonatal hypoxic-ischemic encephalopathy and effectively reduce the incidence of hypoxic-ischemic encephalopathy The incidence of neurological sequelae in children is worthy of clinical promotion and application.