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AIM:To investigate the intestinal barrier changes in ratswith CCl_4-induced portal hypertension.METHODS:The permeability of intestinal barrier detectedby Lanthanum as a tracer was evaluated in rats,Bacterialtranslocation and plasma endotoxin were also determined.RESULTS:The incidence of bacterial translocation was85% in rats with CCl_4-induced portal hypertension,whichwas significantly higher than that in control rats(20%,P<0.01).Plasma endotoxin level was significantly higherin experimental group than in control group.Permeabilityof the epithelial mucosa and pathological alteration wereincreased in the ileum and the microvilli became shorterand thinner in rats with portal hypertension.CONCLUSION:Bacterial translocation occurs in ratswith CCl_4-induced portal hypertension and increasedpermeability between epithelial cells contributes to thetranslocation.
AIM: To investigate the intestinal barrier changes in rats with CCl_4-induced portal hypertension. METHODS: The permeability of intestinal barrier detected by Lanthanum as a tracer was evaluated in rats, Bacterial transit and plasma endotoxin were also determined .RESULTS: The incidence of bacterial translocation was 85% in rats with CCl 4-induced portal hypertension, which was significantly higher than that in control rats (20%, P <0.01) .Plasma endotoxin level was significantly higher in experimental group than in control group. Permeability of the epithelial mucosa and pathological alteration were reinforced in the ileum and the microvilli became shorterand thinner in rats with portal hypertension. CONCLUSION: Bacterial translocation occurs in rats with CCl_4-induced portal hypertension and increased permeability between epithelial cells contributes to the transit site.