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人体组织和细胞在环境氧浓度改变的条件下,通过氧感受器和信号转导通路特异地调节某些基因或蛋白的表达来适应低氧。同时在缺氧情况下,缺氧反应导致多种细胞信号通路的激活参与调节呼吸、代谢、细胞生存等。在哺乳动物体内,HIFs是主要的低氧应激转录因子,其α亚基受到多种因素的影响,如PHDs、FIH1、线粒体、CHIP,本文将在常氧和缺氧状态下,对HIF稳定性调节机制及缺氧所介导相关信号转导通路进行综述。
Human tissues and cells adapt to hypoxia by specifically regulating the expression of certain genes or proteins through oxygen receptors and signal transduction pathways under conditions of altered oxygen concentrations in the environment. At the same time in hypoxia, hypoxia leads to the activation of many cell signaling pathways involved in regulating respiration, metabolism, cell survival and so on. In mammals, HIFs are the major hypoxic stress transcription factors whose α subunits are affected by many factors, such as PHDs, FIH1, mitochondria, and CHIP. In this paper, HIFs are stable in normoxia and hypoxia Sexual regulation mechanism and hypoxia-mediated signal transduction pathways are reviewed.