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目的 :探讨食管鳞状细胞癌原发灶和淋巴结转移灶血管内皮生长因子 (VEGF)表达及微血管形成的规律。方法 :用免疫组化方法测定 35例食管癌标本原发灶和转移灶VEGF表达水平及微血管密度(MVD)。结果 :淋巴结转移灶VEGF表达水平高于原发灶 (P <0 .0 1) ;淋巴结转移灶、原发灶及阴性淋巴结MVD分别为 11 33± 4 .4 4、13 85± 5 57、18 6 1± 6 6 7,淋巴结转移灶与后两者相比差异均有显著性 (P <0 .0 1)。结论 :转移灶VEGF表达水平高于原发灶 ,淋巴结内可能存在抗肿瘤血管生成因素。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) and microvessel formation in the primary tumor and lymph node metastases of esophageal squamous cell carcinoma. Methods : The expression of VEGF and the microvessel density (MVD) were measured by immunohistochemistry in 35 primary esophageal cancer specimens. Results: The expression of VEGF in lymph node metastasis was higher than that in primary tumor (P <0.01). The MVD of lymph node metastases, primary tumor and negative lymph nodes were 11 33 ± 4.44, 13 85 ± 5 57, 18, respectively. The difference of lymph node metastasis between the two groups was significant (P < 0.01). Conclusion : The expression level of VEGF in metastatic lesions is higher than that in primary lesions. There may be anti-angiogenic factors in lymph nodes.