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目的 探讨 p5 3、CD3 4 、E 钙粘蛋白 (E cadherin)在膀胱移行细胞癌中的表达及判断膀胱癌预后的价值。 方法 采用免疫组化方法检测 4 6例膀胱移行细胞癌和 8例正常膀胱粘膜标本p5 3、CD3 4 、E cadherin的表达情况。 结果 4 6例膀胱癌标本中p5 3、E cadherin的异常表达率分别为2 1.7%和 4 5 .6 %。p5 3异常表达在表浅型膀胱癌为 9.1% ,浸润型为 33.3% ,差别有显著性意义 (P <0 .0 5 ) ;病理Ⅰ～Ⅱ级异常表达 7.1% ,Ⅲ级 4 4 .4 % ,差别有显著性意义 (P <0 .0 0 5 ) ;复发组异常表达89 % ,未复发组 15 % ,差别有显著性意义 (P <0 .0 0 5 )。E Cadherin的异常表达率在浅表型膀胱癌为77.3% ,浸润型为 33.3% ,差别有显著性意义 (P <0 .0 0 5 ) ;在Ⅰ、Ⅱ级膀胱癌为 71.4 % ,Ⅲ级为2 7.8% ,差别有显著性意义 (P <0 .0 0 5 ) ;在复发组与未复发组分别为 18.0 %和 6 1.0 % ,差别有显著性意义 (P <0 .0 1)。CD3 4 在膀胱癌中的异常表达率为 4 1.3% ,在不同分期分级及复发与未复发组之间的表达差别均无显著性意义。 结论 p5 3和E Cadherin的异常表达与膀胱癌的恶性程度及复发密切相关 ,可作为判定肿瘤预后和复发的分子生物学指标
Objective To investigate the expression of p53, CD34 and E cadherin in bladder transitional cell carcinoma and to evaluate the prognosis of bladder cancer. Methods Immunohistochemistry was used to detect the expression of p5 3, CD34, E cadherin in 46 cases of transitional cell carcinoma of bladder and 8 cases of normal bladder mucosa. Results The abnormal expression rates of p5 3 and E cadherin in 46 cases of bladder cancer were 27.7% and 45.6% respectively. The abnormal expression of p5 3 was 9.1% in superficial bladder cancer and 33.3% in infiltrative type, with significant difference (P <0.05), abnormal expression of pathological grade Ⅰ ~ Ⅱ was 7.1%, and grade Ⅲ was 44.4 %, Respectively. The difference was significant (P <0.05). The abnormal expression was 89% in the recurrent group and 15% in the non-recurrent group, the difference was significant (P <0.05). The abnormal expression rate of E Cadherin was 77.3% in superficial bladder cancer and 33.3% in infiltrative type, the difference was significant (P <0.05); in grade Ⅰ and Ⅱ bladder cancer was 71.4%, grade Ⅲ (7.8%). There was a significant difference between the two groups (P <0.05). There was a significant difference between the two groups (18.0% and 6.0%, respectively) (P <0.01). The abnormal expression rate of CD3 4 in bladder cancer was 43.3%. There was no significant difference in the expression of CD3 4 between the different stages and between the recurrent and non-recurrent groups. Conclusions The abnormal expressions of p5 3 and E Cadherin are closely related to the malignant degree and recurrence of bladder cancer and can be used as molecular biological indicators to determine the prognosis and recurrence of tumor