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目的:了解两种无细胞百白破疫苗在婴儿群体中免疫接种后的不良反应情况。方法:将3~5月龄的健康婴儿600例分成2组,每组300例,第1组婴儿接种国产吸附无细胞百白破疫苗;第2组婴儿接种进口吸附无细胞百白破疫苗,观察两组婴儿进行免疫接种后1周的不良反应情况。结果:进口吸附无细胞百白破疫苗的免疫接种不良反应率1.0%,局部红肿硬结反应发生率0.7%;国产吸附无细胞百白破疫苗的免疫接种不良反应率4.0%,局部红肿硬结反应发生率5.7%。结论:进口吸附无细胞百白破疫苗的免疫接种不良反应率和局部红肿硬结反应发生率比国产吸附无细胞百白破疫苗低。
Objectives: To understand the adverse reactions of two types of cell-free diphtheria-baed vaccines after immunization in infants. Methods: 600 healthy infants from 3 to 5 months old were divided into two groups (300 in each group). The first group of infants were vaccinated with Chinese-made Adipocyte-Free Pertuced Baitai Vaccine; the second group of infants were vaccinated with Adipocyte-Free Pertuced Baitai Vaccine, Adverse reactions were observed 1 week after immunization in both groups of infants. Results: The rate of adverse reactions of immunization in imported adherent cell-free diphtheriae vaccine was 1.0% and that of local inflamed induration was 0.7%. The rate of adverse reactions of immunization in domestic adherent cell-free diphtheria-pertussis vaccine was 4.0% Rate of 5.7%. Conclusion: The incidence of adverse reactions of immunization and local inflamed induration of imported adherent acellular diphtheriae vaccine is lower than that of domestic adherent acellular diphtheriae vaccine.