Iron-chelating and anti-lipid peroxidation properties of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methy

• 作 者: Kanokwan Kulprachakarn Nittaya
• 机 构: DepartmentofBiochemistry,CollegeofMedicineandPublicHealth,InstituteofResearchandDevelopment,Thalasse
• 出 处: 亚太热带生物医学杂志：英文版
• 发表日期: 2014年8期
• 关键词: Iron-chelating IRON overload Β-THALASSEMIA IRON CHELATOR Non-transferrin bound I
• 基金项目: Supported by the Royal Golden Jubilee PhD Program.Thailand Research Fund(Grant No.PHD/0333/2551)

Objective:To evaluate the iron—chelating properties and free—radical scavenging activities of1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methyIpyridin—4-one(CM1) treatment in chronic iron-loaded β-thalassemic(BKO) mice.Methods:The BKO mice were fed with a ferro