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目的观察运脾化湿中药治疗婴幼儿轮状病毒性肠炎(IRVE)的临床疗效,并观察其对心肌酶谱的影响。方法将80例IRVE患儿随机分为治疗组和对照组各40例,治疗组服用运脾化湿中药,对照组口服思密达,疗程均为3天。观察治疗前后两组患儿腹泻、呕吐、发热的变化,并测定治疗前后心肌酶谱包括血清门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)及肌酸激酶同功酶(CK-MB)。结果治疗组临床疗效及腹泻、发热、呕吐改善情况均显著优于对照组(P<0.01)。治疗后两组的CK-MB、CK和AST值均明显下降(P<0.01或P<0.05),且治疗组降低CK-MB的效果优于对照组(P<0.05);两组LDH值则较治疗前无改善(P>0.05)。结论运脾化湿中药治疗小儿轮状病毒性肠炎具有缩短病程、改善症状、减轻心肌损害的作用。
Objective To observe the clinical efficacy of Yunpi Huashi TCM in the treatment of infantile rotavirus enteritis (IRVE) and to observe its effect on myocardial enzymes. Methods Eighty children with IRVE were randomly divided into treatment group (40 cases) and control group (40 cases). The treatment group took Yunpi Huashi Chinese herbal medicine and the control group took Smecta. The course of treatment was 3 days. The changes of diarrhea, vomiting and fever in both groups before and after treatment were observed. The levels of serum enzymes including serum aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK) and Creatine kinase isoenzyme (CK-MB). Results The clinical efficacy, diarrhea, fever and vomiting in the treatment group were significantly better than those in the control group (P <0.01). After treatment, the CK-MB, CK and AST in both groups were significantly decreased (P <0.01 or P <0.05), and the treatment group decreased CK-MB better than the control group (P <0.05) No improvement than before treatment (P> 0.05). Conclusion Yunpi Huashi decoction for the treatment of children with rotavirus enteritis has shortened the course of disease, improve symptoms and reduce myocardial damage.