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美国糖尿病预防计划的研究目的是评价强化生活方式改变及服用二甲双胍这两种干预措施对于预防2型糖尿病发生的有效性和安全性。共征集3234名志愿者,随机分为强化生活方式改变组、二甲双胍组、安慰剂组。强化生活方式改变组、二甲双胍组糖尿病发病率分别比安慰剂组下降58％和31％,强化生活方式改变组比二甲双胍组下降39％。结果表明膳食与运动干预可有效地延缓2型糖尿病的发生,二甲双胍不仅可以治疗糖尿病,而且可以预防2型糖尿病的发生。
The purpose of the U.S. Diabetes Prevention Program is to evaluate the effectiveness and safety of two interventions that reinforce life style changes and metformin in preventing type 2 diabetes. A total of 3,234 volunteers were enrolled and randomly divided into intensive lifestyle change group, metformin group and placebo group. In the intensive lifestyle modification group, the incidence of diabetes mellitus was 58% and 31% lower in the metformin group than in the placebo group and 39% in the intensive lifestyle modification group compared with the metformin group. The results show that diet and exercise intervention can effectively delay the onset of type 2 diabetes. Metformin can not only treat diabetes, but also prevent type 2 diabetes.