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为选择新药的最佳治疗剂量，必须了解药物在病人体内的药动学。一个药物在个体病人体内的药动学参数可通过测定在有限的几个时间点上所收集的血药浓度来估计。然而，在现有的几种有限采样点策略（limited－samplingstrategy，LSS）设计中，哪种方法最好还没有确定。在一个新型
In order to choose the best therapeutic dose for a new drug, one must understand the pharmacokinetics of the drug in the patient. The pharmacokinetic parameters of a drug in an individual patient can be estimated by measuring the plasma concentration collected over a limited number of time points. However, which of the existing limited-sampling strategy (LSS) designs is best not yet determined. In a new type