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目的观察丁苯酞氯化钠注射液联合低分子肝素钙治疗急性脑梗死患者的临床效果。方法选取2013年11月~2015年11月收治的72例急性脑梗死患者,随机分为对照组和观察组各36例,对照组单用低分子肝素钙治疗,观察组采用丁苯酞氯化钠注射液联合低分子肝素钙治疗,分别于治疗前及治疗后第7 d,使用美国国立卫生研究院卒中量表(the national institutes of health stroke scale,NIHSS)及日常生活活动能力量表(activities of daily living scale,ADL)评定两组患者临床神经功能缺损程度和日常生活活动能力。结果观察组治疗前后NIHSS评分分别为(15.26±2.25)分和(7.26±1.74)分、ADL评分分别为(12.23±8.64)和(65.26±5.75)分,对照组治疗前后NIHSS评分分别为(14.95±2.40)分和(9.63±1.58)分,ADL评分分别为(12.08±8.81)和(45.17±6.35)分;观察组治疗前后NIHSS和ADL评分比较差异均有统计学意义(t=16.876、30.658,均P<0.05),对照组治疗前后NIHSS和ADL评分比较差异均有统计学意义(t=11.109、18.282,均P<0.05);治疗后观察组NIHSS和ADL评分与对照组比较差异均有统计学意义(t=6.050、14.071,均P<0.05)。结论丁苯酞氯化钠注射液联合低分子肝素钙临床疗效较佳,能有效改善急性进展性脑梗死患者的神经功能缺损及日常生活能力,且无严重不良反应,临床能得到满意的疗效。
Objective To observe the clinical effect of butylphthalide and sodium chloride injection combined with low molecular weight heparin in patients with acute cerebral infarction. Methods Seventy-two patients with acute cerebral infarction who were treated from November 2013 to November 2015 were randomly divided into control group (36 cases) and observation group (36 cases). The control group was treated with low molecular weight heparin alone. The observation group was treated with butylphthalide Sodium injection combined with low molecular weight heparin calcium treatment, respectively, before treatment and 7 d after treatment, the use of the National Institutes of Health stroke scale (NIHSS) and daily living activity scale of daily living scale, ADL) assessed clinical neurological deficit and daily living activity in both groups. Results Before and after treatment, the NIHSS scores in the observation group were (15.26 ± 2.25) points and (7.26 ± 1.74) points respectively, and the ADL scores were (12.23 ± 8.64) and (65.26 ± 5.75) points respectively. The NIHSS scores of the control group before and after treatment were 14.95 ± 2.40) points and (9.63 ± 1.58) points respectively. The ADL scores were (12.08 ± 8.81) and (45.17 ± 6.35) points respectively. There was significant difference between the NIHSS and ADL scores in the observation group before and after treatment (t = 16.876 and 30.658 , Both P <0.05). There was significant difference between the NIHSS and ADL scores in the control group before and after treatment (t = 11.109,18.282, all P <0.05). After treatment, NIHSS and ADL scores in the observation group were significantly different from those in the control group Statistical significance (t = 6.050, 14.071, all P <0.05). Conclusions Butylphthalide and sodium chloride injection combined with low molecular weight heparin calcium have better curative effect, which can effectively improve the neurological deficits and daily living ability of patients with acute progressive cerebral infarction without serious adverse reactions and achieve satisfactory clinical results.