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A magnetohydrodynamic (MHD) formulation is derived to investigate and compare the mitigation effects of both the sheared axial flow and finite Larmor radius (FLR) on the Rayleigh-Taylor (RT) instability in Z-pinch implosions. The sheared axial flow is introduced into MHD equations in a conventional way and the FLR effect into the equations via а/аt → -i(ω + ik2⊥ρi2Ωi), as proposed in our previous paper [Chin. Phys. Lett. 2002, 19:217] , where k2⊥ρ2i is referred to FLR effect from the general kinetic theory of magnetized plasma. Therefore the linearized continuity and momentum equations for the perturbed massdensity and velocity include both the sheared axial flow and the FLR effect. It is found that the effect of sheared axial flow with a lower peak velocity can mitigate RT instability in the whole wavenumber region and the effect of sheared axial flow with a higher one can mitigate RT instability only in the large wavenumber region (for normalized wavenumber κ＞ 2.4); The effect of FLR can mitigate RT instability in the whole wavenumber region and the mitigation effect is stronger than that of the sheared axial flow with a lower peak velocity in the almost whole wavenumber region.