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目的：探讨幽门螺杆菌L型（HP－L型）感染与胃癌、癌前病变及慢性胃炎的关系。方法：用组织切片革兰染色和免疫组化法，对36例胃腺癌、34例细胞不典型增生、42例慢性胃炎及15例正常组织进行HP－L型检测。结果：胃癌、不典型增生及慢性胃炎的Hp－L到检出率分别为80．6％、79．4％和73．8％，明显高于正常组织（467％），并有统计学意义（P＜0．05）。而前三种类型组织中的Hp-L型检出率无显著性差异（P＞0．05）。结论:Hp-L型感染与胃癌、癌前病变及慢性胃炎有关，且Hp-L型感染在胃癌的发生中可能起一定作用。
Objective: To investigate the relationship between Helicobacter pylori L-form (HP-L) infection and gastric cancer, precancerous lesions and chronic gastritis. METHODS: HP-L was detected in 36 cases of gastric adenocarcinoma, 34 cases of atypical hyperplasia, 42 cases of chronic gastritis, and 15 cases of normal tissues using tissue section stained with Gram stain and immunohistochemistry. Results: The detection rates of Hp-L in gastric cancer, atypical hyperplasia, and chronic gastritis were 80.6%, 79.4%, and 73.8%, respectively, which were significantly higher than those in normal tissues (467%) and were statistically significant. (P<0.05). There was no significant difference in the detection rate of Hp-L in the first three types of tissues (P>0.05). Conclusion: Hp-L infection is associated with gastric cancer, precancerous lesions and chronic gastritis, and Hp-L infection may play a role in the development of gastric cancer.