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雌激素通过基因和非基因机制可延缓阿尔茨海默病的发生,改善由其导致的认知和记忆功能的障碍,具体作用如下:(1)增强基底部前脑胆碱能系统的功能。(2)增加海马回突触中树突棘密度。(3)减少β-淀粉样蛋白产生。(4)抗自由基和维持钙稳定。
Estrogen can delay the occurrence of Alzheimer’s disease by gene and non-gene mechanisms and improve the cognitive and memory function-induced disorders. The specific actions are as follows: (1) Enhance the function of basal forebrain cholinergic system. (2) increase the density of dendritic spines in the synaptic cleft hippocampus. (3) reduce β-amyloid production. (4) anti-free radicals and maintain calcium stability.