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目的观察金锁固精丸加味方对大鼠阿霉素肾病血液微量元素含量的影响。方法采用阿霉素(6mg/kg)一次性尾静脉注射的方法造成大鼠肾病综合征模型。将实验动物随机分为正常对照组、肾病模型组和金锁固精丸加味方组。观察该方对肾病大鼠24小时尿蛋白、血清总蛋白、白蛋白、总胆固醇、尿素、肌酐、微量元素锌、铜、锰、硒及肾组织形态学的影响。结果金锁固精丸加味方能显著降低肾病大鼠24小时尿蛋白,改善高胆固醇血症及低蛋白血症(P<0.01),减轻肾组织病理变化。模型组血清微量元素锌、铜、锰、硒的含量均明显下降,而金锁固精丸加味方治疗组明显高于模型组(P<0.05或P<0.01),与正常对照组间差异无统计学意义(P>0.05)。结论金锁固精丸加味方对阿霉素肾病良好的治疗作用体现在既能减少阿霉素肾病大鼠尿蛋白的排泄,同时又增加其血清微量元素的含量。
Objective To observe the effects of Jiaoshujing Pill on the content of blood trace elements of adriamycin nephropathy in rats. Methods A rat model of nephrotic syndrome was induced by a single intravenous infusion of doxorubicin (6 mg / kg). The experimental animals were randomly divided into normal control group, model group of nephropathy and Jiaoshou Gujing Pill plus recipe group. To observe the effect of 24 hours urinary protein, serum total protein, albumin, total cholesterol, urea, creatinine, trace elements zinc, copper, manganese, selenium and kidney morphology of nephrosis rats. Results Jinsuo Gujing Pill could significantly decrease 24-hour urinary protein, improve hypercholesterolemia and hypoproteinemia (P <0.01), and alleviate renal pathological changes. The contents of trace elements in the model group, such as zinc, copper, manganese and selenium, decreased obviously, while the treatment group of Jinsuo Gujing Wan plus Wei Fang was significantly higher than the model group (P <0.05 or P <0.01) Statistical significance (P> 0.05). Conclusion The good therapeutic effect of Jiaoshou Jingwan Decoction on doxorubicin nephropathy is not only manifested in reducing excretion of urinary protein in adriamycin-induced nephropathy rats, but also increasing the content of serum trace elements.