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目的:探讨艾迪注射液联合化疗治疗恶性消化道肿瘤的临床疗效。方法:将75例恶性消化道肿瘤患者随机分为两组。对照组37例,单独化疗;治疗组38例,化疗方案同对照组,同时给予艾迪注射液50 m l加入5%葡萄糖注射液或氯化钠注射液450 m l中,静脉滴注,1次/d;连用10 d为1个周期,2~3个周期观察疗效。两组均给予格拉司琼止吐治疗。结果:近期有效率治疗组为65.79%,对照组为43.24%,两组比较P<0.05;毒性反应发生率:治疗组白细胞减少13例(34.21%),血小板减少15例(39.47%);对照组白细胞减少24例(64.86%),血小板减少23例(62.16%);生活质量改善率(等级提高)治疗组为68.42%,对照组为43.24%,两组比较P<0.05。结论:艾迪注射液联合化疗可提高疗效,改善症状,增加患者对化疗的耐受性,提高患者生存质量,同时又可减轻化疗的毒副作用,值得推广应用。
Objective: To investigate the clinical efficacy of Aidi injection combined with chemotherapy in the treatment of malignant gastrointestinal cancer. Methods: Seventy-five patients with malignant gastrointestinal cancer were randomly divided into two groups. 37 patients in the control group were treated with chemotherapy alone; 38 patients in the treatment group were treated with the chemotherapy regimen and the control group. At the same time, 50 ml of Aidi injection was added to 5% glucose injection or sodium chloride injection 450 ml, intravenous drip, once/ d; Use 10 days for 1 cycle, 2 to 3 cycles to observe the effect. Both groups were given granisetron antiemetic treatment. RESULTS: The effective rate was 65.79% in the treatment group and 43.24% in the control group. The incidence of toxicity was 13 cases (34.21%) in the treatment group and 15 cases (39.47%) in the control group. The number of neutropenia was 24 cases (64.86%), and the thrombocytopenia was 23 cases (62.16%). The quality of life improvement rate (grade increase) was 68.42% in the treatment group and 43.24% in the control group. The difference between the two groups was P<0.05. Conclusion: Aidi injection combined with chemotherapy can improve the curative effect, improve the symptoms, increase the patient’s tolerance to chemotherapy, improve the quality of life of patients, and at the same time reduce the toxic side effects of chemotherapy, which is worthy of popularization and application.