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目的:探讨宫颈不典型鳞状上皮细胞(AS-CUS)的组织病理学特点。方法:选取我院收治的210例经宫颈活检明确诊断的AS-CUS患者作为研究对象,对本组患者行阴道镜检查、多点活检及高危HPV-DNA检测,总结、分析AS-CUS的组织病理学结果。结果:阴道镜下活检检出炎症病变145例,宫颈上皮内瘤变65例(30.95%),其中高级别CIN共检出27例。(30~49)岁组的高级别CIN占总例数的9.05%,显著高于≤29岁组(2.38%)和≥50岁组(1.43%),差异均具有统计学意义(P<0.05)。HPV-DNA检测阳性95例(45.24%),阳性组的CIN检出率为57.89%(55/95),阴性组为8.70%(10/115),组间比较差异有统计学意义(P<0.05)。结论:AS-CUS患者多潜存宫颈早期浸润癌或高级别宫颈上皮内瘤变,而高危HPV感染与高级别宫颈上皮内瘤变有着密切联系,临床上应尽早实施阴道镜检查,正确评估检查图像并在阴道镜下做定位活检,可有效提高诊断准确性,降低漏诊率。
Objective: To investigate the histopathological features of cervical atypical squamous cell (AS-CUS). Methods: A total of 210 AS-CUS patients diagnosed by cervical biopsy in our hospital were selected as the research object. Colposcopy, multipoint biopsy and high-risk HPV-DNA detection were performed in this group of patients, and the histopathological features of AS-CUS Rational results. Results: 145 cases of inflammatory lesions and 65 cases of cervical intraepithelial neoplasia (30.95%) were detected by colposcopy biopsy, of which 27 cases were detected by high grade CIN. (30 ~ 49), the high grade CIN accounted for 9.05% of the total cases, which were significantly higher than those of ≤29 years old (2.38%) and ≥50 years old (1.43%), the differences were statistically significant (P <0.05 ). 95 cases (45.24%) were positive for HPV-DNA, 57.89% (55/95) for positive group and 8.70% (10/115) for negative group, the difference between the two groups was statistically significant (P < 0.05). CONCLUSIONS: AS-CUS patients have multi-latent early invasive carcinoma of the cervix or high-grade cervical intraepithelial neoplasia. However, high-risk HPV infection is closely associated with high-grade cervical intraepithelial neoplasia. Colostomy should be performed as soon as possible in clinical practice, Images and positioning colposcopy colposcopy, can effectively improve the diagnostic accuracy, reduce the rate of missed diagnosis.