论文部分内容阅读
目的:观察加味半夏泻心汤联合西药治疗幽门螺杆菌阴性胆汁反流性胃炎的疗效。方法:将78例患者随机分成2组,对照组38例口服莫沙必利胶囊、兰索拉唑肠溶片和铝碳酸镁片,观察组40例在对照组治疗基础上联合加味半夏泻心汤治疗,以2周为1疗程,共治疗2疗程。观察2组疗效,记录症状好转时间,比较2组治疗前后的中医临床症状积分。结果:观察组复查胃镜疗效优于对照组,差异有统计学意义(P<0.05)。治疗2疗程与停药1月后,2组腹痛、烧灼感、胀气、反酸4项症状积分均较治疗前降低(P<0.01)。观察组停药1月后的胀气和反酸积分均高于治疗2疗程后(P<0.01,P<0.05);对照组停药1月后,4项症状积分均高于治疗2疗程后(P<0.01,P<0.05)。治疗2疗程后,观察组4项症状积分均低于对照组(P<0.01,P<0.05);停药1月后,观察组的4项症状积分仍低于对照组(P<0.05)。治疗2疗程后,观察组症状好转时间短于对照组(P<0.05)。2组患者在治疗过程中及治疗后均未出现明显不良反应。结论:加味半夏泻心汤联合常规西药治疗幽门螺杆菌阴性胆汁反流性胃炎的疗效优于单纯西药治疗,改善症状效果明显。
Objective: To observe the effect of Modified Banxiaxiexin Decoction combined with western medicine on Helicobacter pylori negative bile reflux gastritis. Methods: 78 patients were randomly divided into two groups, the control group 38 patients were given mosapride capsules, lansoprazole enteric-coated tablets and aluminum magnesium carbonate tablets, the observation group of 40 patients in the control group based on the combination of flavored Banxiaxie Heart soup treatment to 2 weeks for a course of treatment, a total of 2 courses of treatment. The curative effect of the two groups was observed, and the symptom improvement time was recorded. The clinical symptom scores of the two groups were compared before and after treatment. Results: The efficacy of gastroscopy in the observation group was better than that of the control group, the difference was statistically significant (P <0.05). After 2 courses of treatment and 1 month of withdrawal, the scores of 4 symptoms such as abdominal pain, burning sensation, flatulence and acid reflux were all lower than those before treatment (P <0.01). The flatulence and acid reflux scores of the observation group after 1 month of withdrawal were both higher than those after 2 courses of treatment (P <0.01, P <0.05) P <0.01, P <0.05). After 2 courses of treatment, the four symptom scores in the observation group were lower than those in the control group (P <0.01, P <0.05). After the withdrawal for one month, the four symptom scores in the observation group were still lower than those in the control group (P <0.05). After 2 courses of treatment, the symptom improvement time in the observation group was shorter than that in the control group (P <0.05). Two groups of patients in the course of treatment and after treatment showed no significant adverse reactions. Conclusion: Modified Banxiaxiexin Decoction combined with conventional western medicine in the treatment of Helicobacter pylori negative bile reflux gastritis is superior to western medicine alone, and the effect is obvious.