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弥漫性血管内凝血(简称弥漫凝血)是由于凝血酶进入体循环,使血流中凝血酶增加而引起的一种病理过程。特点是微循环(主要是毛细血管及小静脉)内发生广泛的血小板凝聚和纤维蛋白沉积,造成弥漫性微血栓形成,由此引起凝血因子和血小板大量被消耗,纤维蛋白溶解(下简称纤溶)系统被激活,造成体内组织和器官缺血、坏死。临床上表现为广泛性出血和脏器功能障碍,如不及时抢救,常引起死亡。本症可见于临床各科多种疾病,急性白血病也可发生,特别是急性早幼粒细胞白血病(下简称急早幼粒白血病)最易并发弥漫凝血。本文就有关问题作梗概的介绍,以供参考。
Diffuse intravascular coagulation (diffuse coagulation) is due to thrombin into the systemic circulation, so that increased blood flow thrombin caused by a pathological process. It is characterized by extensive platelet aggregation and fibrin deposition within the microcirculation (mainly the capillaries and venules), resulting in diffuse microthrombi formation, which in turn causes massive consumption of clotting factors and platelets, fibrinolysis (hereinafter referred to as fibrinolysis The system is activated, causing ischemia and necrosis of tissues and organs in the body. Clinical manifestations of extensive bleeding and organ dysfunction, if not rescued, often causing death. This disease can be found in various clinical diseases, acute leukemia can also occur, especially acute promyelocytic leukemia (hereinafter referred to as acute promyelocytic leukemia) most likely complicated by diffuse coagulation. This article gives a synopsis of the relevant issues for reference.