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随着高分子材料学和纳米技术的不断发展,纳米递释系统在药剂学领域的应用潜力逐渐彰显,尤其在基因/药物传递中具有明显的优势。与单一的药物递释系统相比,基因与药物共载递释系统通过增强基因的转染率和逆转多药耐药性等作用,可以明显提高药物的治疗效果。递释系统中引入环境响应性(p H响应、还原响应和光响应等)基团,构建肿瘤内外环境触发释放基因与药物共载递释系统,可以进一步提高抗肿瘤治疗效果。本文综述了近年来环境响应性递释系统在共载基因与药物中的应用进展,分析并总结其在抗肿瘤治疗方面的显著特性。
With the continuous development of macromolecular materials science and nanotechnology, the potential application of nano-delivery system in the field of pharmacy has been gradually highlighted, especially in the gene / drug delivery has obvious advantages. Compared with a single drug delivery system, the gene and drug-loaded delivery system can significantly improve the therapeutic effect of the drug by enhancing the gene transfection rate and reversing multi-drug resistance. The introduction of environmental responsive (p H response, reduction response and light response, etc.) groups into the system of delivery and delivery, and the construction of a drug-controlled release-release gene and drug delivery system inside and outside the tumor can further improve the anti-tumor therapeutic effect. This review summarizes the progress in the application of environment-responsive delivery systems in drug-loaded genes in recent years, and analyzes and summarizes its salient features in anti-cancer therapy.