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目的评价选择性动脉溶栓治疗急性脑梗死的疗效和安全性。方法2003年1月～2005年5月期间对25例急性脑梗死患者进行选择性动脉溶栓,同期选择年龄、病情相匹配的无溶栓的对照患者25例,同时采用卒中登记方法收集选择性动脉溶栓患者及同期无溶栓的对照患者的临床、实验室及影像学等资料,前瞻性随访所有患者6个月的预后。结果溶栓组和对照组1个月末的病死率分别为4%和4%,6个月末的病死率分别为4%和4%;溶栓组和对照组1个月末残疾率分别为16%和40%,6个月末的残疾率分别为4%和24%。溶栓组并发脑出血2例(8%),其中症状性脑出血1例(4%);对照组未发生症状性脑出血。结论选择性动脉溶栓治疗急性脑梗死患者有效和安全。
Objective To evaluate the efficacy and safety of selective arterial thrombolysis in the treatment of acute cerebral infarction. Methods Twenty-five patients with acute cerebral infarction underwent selective arterial thrombolysis during the period from January 2003 to May 2005. Twenty-five matched patients without thrombolysis were enrolled in the same period. Their seizure selectivity Arterial thrombolysis patients and control patients without thrombolysis during the same period of clinical, laboratory and imaging data, prospective follow-up of all patients 6 months prognosis. Results The mortality rates at the end of one month in the thrombolytic group and the control group were 4% and 4%, respectively, and the mortality rates at the end of 6 months were 4% and 4% respectively. The 1-month residual rates of thrombolytic group and control group were 16% And 40% respectively, with the rates of disability at the end of 6 months being 4% and 24% respectively. Thrombolytic group complicated with intracerebral hemorrhage in 2 cases (8%), including symptomatic intracerebral hemorrhage in 1 case (4%); control group did not occur symptomatic intracerebral hemorrhage. Conclusion Selective arterial thrombolysis in patients with acute cerebral infarction is effective and safe.