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目的:探讨慢性粒细胞白血病(CML)患者在3种不同病期中血液流变学的改变。方法:选取56例初诊的CML病人,未经化疗,利用FASCO3010A全自动血流变仪测其血液流变学部分指标进行统计分析。结果:CML慢性期患者b、HCT、ESR、Kesr、RE、Fg、DI值显著高于正常对照组(P<0.05或P<0.01),IR值显著低于正常对照组(P<0.01)。加速期患者除ESR.、Fg显著高于正常对照组(P<0.01),其余指标均与正常对照组差异无显著性(P>0.05)。急变期患者b、HCT、Kesr、RE、DI值均显著低于正常对照组(P<0.05或P<0.01)。而ESR、Fg、p均显著高于正常对照组(P<0.05或P<0.01)。结论:CML慢性期病人并发血栓的危险性最大;CML三种病期中ESR、Fg始终处于较高水平。提示:Fg含量的增加可以导致红细胞聚集性增强,是直接促进白血病细胞转移和扩散的主要原因。
Objective: To investigate the changes of hemorheology in three different stages of patients with chronic myeloid leukemia (CML). Methods: Fifty-six newly diagnosed CML patients were selected and analyzed by FASCO3010A automatic hemorrheology instrument for hemorheology without chemotherapy. Results: The values of b, HCT, ESR, Kesr, RE, Fg and DI in patients with chronic phase CML were significantly higher than those in normal control group (P <0.05 or P <0.01), and IR values were significantly lower than those in normal control group (P <0.01). In addition to ESR, patients with accelerated phase Fg was significantly higher than the normal control group (P <0.01), and the remaining indicators were not significantly different from the normal control group (P> 0.05). The values of b, HCT, Kesr, RE and DI in patients with acute phase were significantly lower than those in normal control group (P <0.05 or P <0.01). While the ESR, Fg, p were significantly higher than the normal control group (P <0.05 or P <0.01). Conclusion: The risk of thrombosis in patients with chronic phase of CML is the highest. ESR and Fg in CML are always at a high level. Tip: Increased Fg content can lead to enhanced erythrocyte aggregation, is directly promote leukemia cell metastasis and proliferation of the main reasons.