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目的 为探讨 2型糖尿病血糖与胰岛素释放的关系 ,我们研究了不同血糖水平对胰岛β细胞释放胰岛素的影响。方法 98例 2型糖尿病患者停用口服降糖药 4 8h后做口服 75g葡萄糖耐量试验 (OGTT)及胰岛素释放试验 (IRT) ,对血糖和胰岛素结果进行相关分析 ,同时评价空腹和口服葡萄糖后血糖的高低、峰值血糖的时相、血糖峰基比等对基础和糖刺激后胰岛素释放的影响。结果 OGTT血糖水平与基础有的是无明显相关 ,与刺激后胰岛素水平呈明显负相关 ,尤其是与峰值胰岛素 (Imax)和胰岛素峰基比 (M/B1)呈负相关 ;基础血糖大于11 1mol/L的Imax和M/B1大约是基础血糖小于 11 1mol/L的三分之一 (P <0 0 1) ,峰值血糖大于 16 7mol/L的Imax和M/B1也明显胝于峰值血糖较小者 (P <0 0 1～ 0 0 5 ) ;峰值血糖时相越延迟 ,Imax和M/B1就越低 ;血糖峰基比大于 2者的Imax和M/B1高于较小者 (P <0 0 1)。结论 2型糖尿病的高血糖 (基础或糖负荷后血糖 )对葡萄糖刺激的胰岛素释放水平具有明显的损害作用 ,对基础胰岛素水平影响不大
Objective To investigate the relationship between type 2 diabetes mellitus and insulin release, we investigated the effects of different blood glucose levels on islet β-cell insulin release. Methods 98 patients with type 2 diabetes were treated with oral glucose tolerance test (OGTT) and insulin release test (IRT) after oral hypoglycemic agents were withdrawn for 48 hours. The correlations between blood glucose and insulin were analyzed and the post-glucose and post-glucose glucose The level of peak blood glucose, blood glucose peak to base ratio and insulin stimulation after insulin release. Results There was no significant correlation between OGTT blood glucose level and basal insulin level, but negatively correlated with stimulated insulin level, especially with peak insulin (Imax) and insulin peak ratio (M / B1). The basal blood glucose was more than 11 1 mol / L Imax and M / B1 were about one-third of those with basal glycemia <11 1 mol / L (P <0.01), and Imax and M / B1 with peak glucose above 16 7 mol / L were also significantly higher than those with less peak glucose (P <0.01-0.05). The longer the peak blood glucose phase was, the lower the Imax and M / B1 were. The higher the Imax and M / B1 blood glucose peak ratio were 0 1). Conclusions Hyperglycemia (basal or glycemic sugar load) in type 2 diabetic patients has a significant detrimental effect on glucose-stimulated insulin release with little effect on basal insulin levels