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由于先天性缺陷或免疫抑制治疗致成淋巴细胞功能受损害而免疫功能低下的人,其癌的发病率高于常人;当恶性肿瘤患者具有正常的合成抗肿瘤抗体的淋巴细胞免疫系统时,其恶性病变播散率低于检察不到此种抗体的病人。患造血系统恶性病病人的淋巴细胞显示细胞内N-乙酰-β-氨基葡萄糖苷酶(N-acetyl-beta-glucosaminidase),β-葡萄糖醛酸酶(beta-glucuronidase),以及酸性磷酸酶的含量降低。喉癌患者淋巴细胞内的溶酶体酶(lysosomal enzymes)由溶酶体内重新分布进入周围细胞浆中。这些淋巴细胞酶的再分布,反映了细胞生物活性和对抗原刺激的反应。头颈部癌患者体外实验证明功能异常的淋巴细胞,对檀物血凝素(PHA)刺激,表现为低反应性。
People with immunocompromised impaired lymphocyte function due to congenital defects or immunosuppressive therapy have a higher prevalence of cancer than normal people; and when a malignant tumor patient has a normal lymphocyte immune system that synthesizes an anti-tumor antibody, Disseminated malignant lesions were lower than those who did not receive such antibodies. Lymphocytes from patients with hematopoietic malignancies showed intracellular N-acetyl-beta-glucosaminidase, beta-glucuronidase, and acid phosphatase reduce. Lysosomal enzymes in lymphocytes of patients with laryngeal cancer are redistributed into the surrounding cytoplasm by lysosomes. The redistribution of these lymphocyte enzymes reflects cellular biological activity and response to antigen stimulation. Head and neck cancer patients in vitro experiments show that dysfunctional lymphocytes, hemagglutinin (PHA) stimulation, showed low reactivity.