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目的探讨P选择素与急性冠脉综合征合并糖尿病患者冠脉病变严重程度的相关性。方法检测48例急性冠脉综合征合并糖尿病(ACS合并糖尿病组)患者,40例急性冠脉综合征(单纯ACS组)患者,30例健康对照组血清P选择素水平;研究冠状动脉病变支数、左主干病变、冠脉Gensini评分与P选择素水平的相关性。结果 ACS合并糖尿病组、单纯ACS组P选择素水平、冠脉Gensini评分显著高于正常对照组(P<0.01),ACS合并糖尿病P选择素水平、冠脉Gensini评分显著高于单纯ACS组(P<0.01)。与冠状动脉1支病变和2支病变组比较,3支病变或左主干病变患者P选择素水平显著升高,差异有统计学意义(P<0.01)。结论急性冠脉综合征合并糖尿病患者P选择素水平明显升高,和冠状动脉病变程度之间存在相关性。
Objective To investigate the relationship between P-selectin and the severity of coronary artery disease in patients with acute coronary syndrome and diabetes mellitus. Methods The serum levels of P-selectin in 48 patients with acute coronary syndrome complicated by diabetes mellitus (ACS with diabetes mellitus), 40 patients with acute coronary syndrome (ACS group) and 30 healthy controls were measured. The number of coronary artery lesions , Left main lesion, coronary Gensini score and P-selectin level. Results The P-selectin level and Gensini score of coronary ACS group were significantly higher than those of ACS group (P <0.01), P-selectin level of ACS with diabetes mellitus group and Coronary artery Gensini score group were significantly higher than ACS group <0.01). Compared with 1 coronary artery disease and 2 lesions group, the P-selectin level in 3 lesions or left main trunk lesions was significantly increased, the difference was statistically significant (P <0.01). Conclusion The P-selectin level in patients with acute coronary syndrome complicated with diabetes mellitus is significantly increased, which correlates with the degree of coronary artery lesion.