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对153名二氧化硅粉尘作业工人（接尘组）和84名年龄相当但不接尘及其它毒物者（对照组）肾功能进行调查。结果发现接尘工人尿NAG活性及尿α1－MG、β2-MG、A1b含量较对照组显著升高，且随接尘工龄延长而明显升高，呈剂量-反应关系。若以超过对照组95％单侧上限值为阳性标难，则尿α1－MG、β2-MG、A1b、NAG阳性率增高有显著意义，且尿酶与尿蛋白各指标之间呈正相关关系。表明长期接触含游离二氧化硅的粉尘除可引起呼吸系统功能损害外，尚可导致肾小球和肾小管的混合性损伤。提示尿α1－MG、β2-MG、A1b、NAG测定可作为矽尘所致慢性肾损害的敏感检测指标。
A total of 153 silica dust workers (dust-pick group) and 84 age-matched but non-dust and other toxicants (control group) were investigated for renal function. The results showed that urinary NAG activity and urinary α1-MG, β2-MG and A1b contents of workers exposed to dust were significantly higher than those of the control group, and were significantly increased with the prolongation of the dusting life, showing a dose-response relationship. The positive rate of urinary α1-MG, β2-MG, A1b and NAG was significantly increased if the unilateral upper limit of 95% of the control group was positive, and there was a positive correlation between each index of urinary enzymes and urinary protein . Show that long-term exposure to dust containing free silica in addition to causing respiratory dysfunction, can still lead to mixed glomerular and tubular injury. Urine α1-MG, β2-MG, A1b, NAG determination can be used as sensitive indicators of silica dust-induced renal damage.