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本文研究了３Ｈ－ＴＮＴ在大鼠体内的毒物动力学。ＴＮＴ的生物半衰期为９．３ｈ，经气管内注入ＴＮＴ的生物利用度为８８．１７％。ＴＮＴ在工人体内的代谢物２．６－二硝基－４－氨基甲苯（ＤＮＡＴ）主要经尿排出，其排出量与ＴＮＴ接触水平有关，与ＴＮＴ皮肤污染量相关更为密切，提示有接触水平－效应关系，测定尿中ＤＮＡＴ可作为职业接触ＴＮＴ的生物监测指标。根据ＴＮＴ毒物动力学参数和ＴＬＶ值的推算结果，结合职业接触ＴＮＴ的人群资料，参考非接触人群尿中ＤＮＡＴ的本底值，初步提出ＴＮＴ生物接触指数（ＢＥＩ）为１ｍｇ／Ｌ。
This article studies the toxicokinetics of 3H-TNT in rats. The biological half-life of TNT was 9.3h, and the bioavailability of TNT intratracheally was 88.17%. TNT metabolites in the body of workers mainly excreted by urine, the amount of TNAT exposure and TNT exposure was related to TNT skin contamination more closely, suggesting a contact level - effect, determination of DNAT in urine can be used as biological monitoring indicators of occupational exposure to TNT. According to the results of TNT toxicokinetic parameters and TLV values, combined with the data of occupational exposure to TNT and the reference value of DNAT in urine of non-contact population, the bioassay index (BEI) of TNT was initially proposed to be 1mg / L.