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目的 :探讨脑梗塞 (CI)病人红细胞膜Na+ K+ ATPase、Ca2 + Mg2 + ATPase与血液流变学指标的相关性。方法 :对 49例非急性期的脑梗塞患者和 2 9例健康人分别测定Na+ K+ ATPase、Ca2 + Mg2 +ATPase、Ox LDL、LDL C、Cho C以及血液流变学指标。结果 :CI组全血粘度、血浆粘度、还原粘度、HCT、EAI、TK与Na+ K+ ATPase、Ca2 + Mg2 + ATPase活力的变化呈明显负相关 ;与Ox LDL、LDL C、Cho C呈明显正相关。结论 :CI患者红细胞膜泵活性的变化能引起血液粘滞性的改变 ,其作用主要是红细胞膜Na+ K+ 泵、Ca2 + 泵的活性降低 ,导致红细胞变形能力下降。
Objective: To investigate the correlation between erythrocyte membrane Na + K + ATPase, Ca2 + Mg2 + ATPase and hemorheology in patients with cerebral infarction (CI). Methods: The levels of Na + K + ATPase, Ca2 + Mg2 + ATPase, Ox LDL, LDL C, Cho C and hemorheology were measured in 49 non-acute cerebral infarction patients and 29 healthy controls. Results: The changes of whole blood viscosity, plasma viscosity, reducing viscosity, HCT, EAI and TK in CI group were negatively correlated with the activities of Na + K + ATPase and Ca2 + Mg2 + ATPase, and positively correlated with Ox LDL, LDL C and Cho C . CONCLUSION: The changes of erythrocyte membrane pump activity in CI patients can cause the change of blood viscosity. The main function of CIK is the Na + K + pump of erythrocyte membrane, and the activity of Ca2 + pump decreases, resulting in the decrease of erythrocyte deformability.