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本文报道了对185名沥青作业工人和33名对照者的调查结果。检查项目为谷胱甘肽过氧化物酶、脂质过氧化、血清唾液酸及乳酸脱氢酶同工酶。各项观察指标反映生物膜损伤结果一致。脂质过氧化、血清唾液酸、乳酸脱氢酶同工酶(LDH_3)三项指标均明显增高,与对照组比较差异有显著意义(P值分别小于0.001、0.01和0.05)。谷胱甘肽过氧化物酶活性明显下降,与对照组比较差异有极显著意义(P<0.001)。结果表明,沥青对作业工人的生物膜有损伤作用,特别表现在对肺组织的损伤。这种膜损伤可能是肺癌产生的机理,其内在联系尚需进一步探讨。作者认为上述四项指标叫作为沥青接触工人肺组织早期损害的监护指标。
This paper reports the results of a survey of 185 asphaltic workers and 33 controls. Check the project for glutathione peroxidase, lipid peroxidation, serum sialic acid and lactate dehydrogenase isoenzyme. The observation indicators reflect the same biofilm damage results. Lipid peroxidation, serum sialic acid, lactate dehydrogenase isoenzyme (LDH_3) three indicators were significantly increased, compared with the control group was significantly different (P values were less than 0.001,0.01 and 0.05). Glutathione peroxidase activity was significantly decreased, compared with the control group, the difference was significant (P <0.001). The results show that bitumen has a damaging effect on the biofilm of working workers, especially in lung tissue damage. This membrane damage may be the mechanism of lung cancer, the intrinsic link remains to be further explored. The authors believe that the above four indicators are called indicators for the monitoring of early damage of lung tissue by asphalt exposed workers.