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目的 观察窒息新生儿免疫功能及 β 内啡肽 (β EP)的动态变化。 方法 2 0 0 1年 10月至 2 0 0 2年 10月选择广东省肇庆市第一医院儿科住院窒息新生儿 81例和同期健康新生儿 2 0例。窒息儿随机分成两组 :常规治疗组 4 1例和纳络酮治疗组 4 0例。均于生后第 1和第 7天两次采血 ,分别检测 β EP、IL 2、TNF α、CD3、CD4、CD8、IgA、IgM、IgG及CH50 等各项指标。结果 生后第 1天与对照组相比窒息组新生儿免疫功能明显抑制 ,且与窒息程度成正比 ,而 β EP则显著升高 ;生后第 7天 ,常规治疗组与对照组比较 ,β EP、IL 2、TNF α、CD3、CD4 /CD8等项仍有显著差异 (P <0 0 5 ) ,而纳络酮治疗组和常规治疗组比较 ,则 β EP、IL 2、TNF α、CD3、CD8、CD4 /CD8等项有显著差异 (P <0 0 5 ) ;除CD8外 ,常规治疗组 β EP与各免疫指标两次检测差值的相关分析均有显著相关性 (P <0 0 5 )。结论 窒息新生儿免疫功能明显抑制 ,且与窒息程度成正比 ,β EP参与了其中免疫的抑制性调节
Objective To observe the changes of immune function and β-endorphin (β EP) in neonates with asphyxia. Methods From October 2001 to October 2002, 81 neonates with asphyxia and 20 healthy neonates were selected as the pediatric inpatients of Zhaoqing First Hospital of Guangdong Province. Asphyxia children were randomly divided into two groups: conventional treatment group 41 cases and naloxone treatment group 40 cases. Both blood samples were collected twice on the 1st and 7th day after birth. The indexes of β EP, IL 2, TNF α, CD 3, CD4, CD8, IgA, IgM, IgG and CH50 were detected. Results On the first day after birth, the immune function of neonates with asphyxia group was significantly inhibited compared with that of the control group, and was positively correlated with the degree of asphyxia, while β EP was significantly increased. On the 7th day after birth, compared with the control group, β EP, IL 2, TNFα, CD3, CD4 / CD8 and other items were still significantly different (P <0 05), while the naloxone treatment group compared with the conventional treatment group, the β EP, IL 2, TNF α, CD3 , CD8, CD4 / CD8 and other items were significantly different (P <0 05). In addition to CD8, there was a significant correlation between β EP and the two detection differences of each immune index (P <0 0 5). Conclusion Asphyxia neonatal immune function was significantly inhibited, and with the degree of asphyxia is proportional to, β EP involved in which immunosuppressive regulation