论文部分内容阅读
为探讨一氧化氮 (NO)在慢性阻塞性肺疾病 (COPD)发病中的作用及吸入NO对COPD肺功能的影响 ,本研究检测了COPD患者鼻、口呼出气中NO的含量及吸入不同浓度 (10～ 80ppm)NO时肺功能和血气指标。结果表明 :COPD患者鼻、口呼出气NO含量均明显低于对照组 (P <0 .0 1) ,且COPD和对照组口呼出气NO含量低于鼻呼出气 (P <0 .0 1) ;吸入 2 0～ 80ppmNO能明显改善COPD患者部分肺通气功能指标(FEV1、FEV1/FVC、FEV1%、PEF) ,且呈效量依赖关系 ,但对肺容量和肺弥散功能指标无明显影响 ;吸入NO后COPD患者PaCO2 增加 ,但对PaCO2 和高铁血红蛋白无明显影响。提示NO合成减少可能介导了COPD的发病 ,吸入一定浓度的NO可改善COPD患者肺通气功能和PaO2
In order to explore the role of nitric oxide (NO) in the pathogenesis of chronic obstructive pulmonary disease (COPD) and the effect of inhaled NO on the lung function of COPD, this study examined the NO content of exhaled breath from the nose and mouth of COPD patients, (10 ~ 80ppm) NO lung function and blood gas indicators. The results showed that the content of NO in the nasal and oral exhaled air of patients with COPD was significantly lower than that of the control group (P <0.01), and the NO content of exhaled breath in the COPD and control groups was lower than that of the nasal exhaled air (P <0.01) (FEV1, FEV1 / FVC, FEV1%, PEF) in 20 COPD patients were significantly improved with inhalation of 20 ~ 80ppmNO, and there was no significant effect on lung volume and pulmonary diffuse function index. PaCO2 in patients with COPD increased NO, but no significant effect on PaCO2 and methemoglobin. Suggesting that decreased NO synthesis may mediate the pathogenesis of COPD. Inhalation of certain concentrations of NO may improve pulmonary ventilation and PaO2 in COPD patients