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对急性早幼粒细胞白血病42例应用全反式维甲酸诱导治疗达完全缓解后,分别采用化疗与维甲酸序贯治疗和单用维甲酸维持。经随访,前者2~5年生存率显著高于后者;而复发率则显著低于后者。提示,序贯治疗效果优于单用维甲酸维持。
For 42 cases of acute promyelocytic leukemia treated with all-trans retinoic acid induced complete remission, followed by sequential chemotherapy with retinoic acid and maintenance with retinoic acid alone. After follow-up, the survival rate of the former was significantly higher than the latter in 2 to 5 years; the recurrence rate was significantly lower than the latter. It is suggested that sequential treatment is better than single use of retinoic acid.