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心脏再同步化治疗已经成为治疗心力衰竭一种重要的非药物方法，其可改善房室、室间和室内的同步性。功能性二尖瓣反流在心力衰竭患者较为常见，且其出现对患者生存率成负性影响。目前国内外关于心脏再同步化治疗减少二尖瓣反流已有大量研究，现对心脏再同步化治疗减少二尖瓣反流的机制、临床意义及影响进行系统阐述。“,”Cardiac resynchronization therapy is an important method for treating heart failure,which can improve the atrioventricular, interventricular and intraventricular synchronism.Functional mitral regurgitation is a common finding in patients with heart failure, and the presence of mitral regurgitation in patients with heart failure is an independent predictor of worsened survival.There are many researches a-bout cardiac resynchronization therapy of reducing mitral regurgitation in the domestic and overseas.This review will discuss the mechanisms of reduction of mitral regurgitation by cardiac resynchronization therapy and clinical significance and implications of reduction of mitral regur-gitation by cardiac resynchronization therapy.