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目的:分析深圳市南山区2006～2012年出生缺陷发生情况、流行病学特征及影响因素,为制定干预措施提供科学依据。方法:对2006～2012年深圳市南山区全人口出生缺陷监测报告病例进行流行病学分析。结果:7年间监测115 620例围产儿,其中出生缺陷儿2017例,平均出生缺陷发生率174.45/万。出生缺陷前5种疾病排序依次为先天性心脏病547例,发生率4.73‰,构成比27.12%;指(趾)、肢体畸形406例,发生率3.53‰,构成比20.13%;唇裂、腭裂及唇腭裂174例,发生率1.50‰,构成比8.63%;外耳畸形136例,发生率1.18‰,构成比6.74%;神经管畸形99例,发生率0.86‰,构成比4.91%。结论:加大健康教育的宣传力度,大力实施出生缺陷干预工程,加强围产期保健工作质量和三级预防队伍建设,提升出生缺陷产前监测质量,制定多方面的干预措施,降低出生缺陷的发生率。
OBJECTIVE: To analyze the occurrence, epidemiological characteristics and influencing factors of birth defects in Nanshan District of Shenzhen City from 2006 to 2012, and provide a scientific basis for the formulation of intervention measures. Methods: The epidemiological analysis of all the birth defects in Nanshan District from 2006 to 2012 was conducted. Results: A total of 115 620 perinatal children were monitored over a seven-year period. Among them, 2017 were born with defective births and the average incidence of birth defects was 174.45 per 10,000. The order of the top 5 birth defects was 547 cases of congenital heart disease, with a incidence rate of 4.73 ‰ and a composition ratio of 27.12%. Finger and digit deformities were 406 and the incidence rate was 3.53 ‰, constituting a ratio of 20.13%. Cleft lip and cleft palate There were 174 cases of cleft lip and palate, the incidence rate was 1.50 ‰, the ratio of 8.63%; 136 cases of external ear deformity, the incidence rate was 1.18 ‰, accounting for 6.74%; 99 cases of neural tube defects, the incidence rate of 0.86 ‰, the ratio of 4.91%. CONCLUSIONS: Publicity of health education should be stepped up, the birth defects intervention project should be vigorously implemented, the quality of perinatal health care work and the construction of tertiary prevention teams should be strengthened, the quality of prenatal monitoring of birth defects should be improved, various interventions should be made to reduce birth defects Occurrence rate.