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目的研究大剂量尿激酶溶栓治疗急性脑梗死的临床效果并探讨临床应用前景。方法 88例急性脑梗死患者,随机分成对照组和观察组,各44例。对照组患者采用低分子肝素进行治疗,观察组患者采用大剂量尿激酶溶栓进行治疗,对比两组患者治疗效果、治疗前后凝血与纤溶相关指标变化情况,以及神经功能缺损程度评分。结果观察组总有效率为95.5%,高于对照组患者的63.6%,差异具有统计学意义(P<0.05)。治疗24 h后,观察组凝血与纤溶相关指标均优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者神经功能缺损程度评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论大剂量尿激酶溶栓治疗急性脑梗死效果好,且对神经功能的缺损较小,值得临床推广使用。
Objective To study the clinical effect of high-dose urokinase thrombolytic therapy on acute cerebral infarction and to explore the clinical application prospects. Methods 88 patients with acute cerebral infarction were randomly divided into control group and observation group, 44 cases in each group. The patients in the control group were treated with low molecular weight heparin. The patients in the observation group were treated with high-dose urokinase thrombolysis. The curative effect, the change of coagulation and fibrinolysis before and after treatment, and the score of neurological deficit were compared between the two groups. Results The total effective rate in observation group was 95.5%, which was higher than that in control group (63.6%), the difference was statistically significant (P <0.05). After treatment for 24 h, the indexes of coagulation and fibrinolysis in the observation group were better than those in the control group, with statistical significance (P <0.05). After treatment, the score of neurological deficit in both groups was lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant (P <0.05). Conclusion High-dose urokinase thrombolytic therapy for acute cerebral infarction is effective, and the defect of neurological function is small, worthy of clinical promotion and use.