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中药地骨皮是植物构杞(Lycium chinense Mill. 的根皮,临床上有降压效果。曾报道对实验动物有降压、降血糖、解热和抗应激性(疒贵)疡活性。曾从日本产地骨皮分得甜菜碱,中国产地骨皮分得甜菜碱、一种植物甾醇和亚油酸,但这些化合物均无上述生理活性。作者发现,地骨皮的甲醇提取物对大鼠有明显降压作用(静脉注射,粗生药0.5g/kg),故将甲醇提取物反复层析(硅胶/乙酸乙酯和甲醇),除得到甜菜碱和胆碱外,还获得一活性部分。进一步层析(大孔吸附树脂AmberliteXAD-2/水和乙醇;葡聚糖凝胶LH-20/甲醇)得到无定形生物碱,命名地骨皮甲素(Kukoamine A)(I),C_(28)H_(42)N_4O_6(FD-MSm/e 530,M~+),证明I含胺基和酚
Chinese medicine Digupi is the root bark of Lycium chinense Mill.It is clinically effective in lowering blood pressure.Hypotension, hypoglycemic, antipyretic and anti-stressful ulcer activity have been reported in experimental animals. Bone derived from Japanese origin betaine, bone Chinese origin divided betaine, a phytosterol and linoleic acid, but none of these compounds have the above physiological activity.The authors found that the Digupi methanol extract on the large Rat has a significant antihypertensive effect (intravenous injection, crude drug 0.5g / kg), so the methanol extract repeated chromatography (silica gel / ethyl acetate and methanol), in addition to get betaine and choline, but also to obtain an active part . Further chromatography (macroporous adsorption resin Amberlite XAD-2 / water and ethanol; Sephadex LH-20 / methanol) gave amorphous alkaloids named Kukoamine A (I) 28) H_ (42) N_4O_6 (FD-MSm / e 530, M ~ +)