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中缝背核及导水管周围灰质区,已有不少资料证明在针刺镇痛中有重要作用。该处是5-羟色胺(5-HT)神经元及阿片受体分布密集区。是处理痛觉信息的重要“驿站”,研究其中5-HT 和内啡肽对针刺镇痛的作用当有一定的意义。应用5-HT 能神经元化学切除剂5.6-两羟色胺(5.6-DHT)及阿片受体拮抗剂纳洛酮(naloxone)分别注入中缝背核及邻近灰质区,都有明显对抗或减弱电针镇痛效应,说明电针过程中受两者的双重支配,该处注射微量吗啡并可与电针镇痛有显著协同效应,更说明两者的参与。在实验中看到5.6-DHT 对抗电针镇痛的作用强于纳洛酮的作用,当应用5.6-DHT 明显减弱针效时,再注纳洛酮仍可进一步翻转剩余的部分针效。但其翻转率明显变小。似乎说明肽能神经元在针刺镇痛中有赖于5-HT 能神经元的完整。该处注射亮氨酸脑啡肽(150μg)可产生较弱的镇痛作用,也不与电针镇痛协同,因例数太少,有待进一步研究。
Dorsal raphe and the periaqueductal gray zone, there are many data prove that acupuncture analgesic has an important role. This area is serotonin (5-HT) neurons and opioid receptor-rich areas. Is to deal with pain information important “inn” to study the role of 5-HT and endorphins on acupuncture analgesia when there is a certain significance. Application of 5-HT neuron chemotaxis 5.6-HT (5.6-DHT) and opioid receptor antagonist naloxone were injected into the dorsal raphe nucleus and adjacent gray matter areas, respectively, with significant antagonism or attenuation of electroacupuncture Pain effect, indicating that the process of electroacupuncture by the dual control of both, where the injection of trace morphine and analgesic EA may have a significant synergistic effect, but also shows the participation of both. In the experiment, 5.6-DHT was found to be more effective against electroacupuncture analgesia than naloxone. When 5.6-DHT markedly attenuated acupuncture effects, re-injection of naloxone further reversed the remaining part of acupuncture effects. However, its turnover rate was significantly smaller. It seems that peptide neurons rely on the integrity of 5-HT neurons in acupuncture analgesia. The injection of leucine enkephalin (150μg) can produce weaker analgesic effect, nor synergistic with EA analgesia, because the number of cases is too small for further study.