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胎儿及新生儿重度窒息,即使抢救成功,也会遗留轻微的脑障碍后遗症。脑是机体内需要能量最多的器官。其能量几乎全部来自葡萄糖。当脑循环障碍时,氧及葡萄糖供应减少,使脑细胞受损,则引起轻微脑障碍综合征。葡萄糖有两条分解途径,即厌氧的古典途径和需氧的三羧酸循环,成人的葡萄糖厌氧代谢约占15%。在高度需要能量或氧供应减少时,厌氧代谢明显增加。还原辅酶I(NADH)是糖酵解系统能量代谢的重要辅酶,探索其分布密度是研究脑代谢的重要手段。NADH具有特有的荧光,可根据其分布的密度检查实验动物的胎仔、新生仔生理状况和重度窒息时脑的能量代谢。方法:用妊娠28～31日的母兔11只所生的仔兔共56只(体重32～65g),在生后2日内进行实验。其中将心率在140bpm以上的不给任何负荷的新生
Fetal and neonatal severe asphyxia, even if the rescue is successful, there will be slight leftovers brain disorders. The brain is the organ that requires the most energy in the body. Almost all of its energy comes from glucose. When brain circulatory disorders, oxygen and glucose supply decreased, so that brain cells damaged, then cause mild brain disorder syndrome. There are two ways to break down glucose, that is, the anaerobic classic pathway and the aerobic TCA cycle. The anaerobic metabolism of glucose in adults accounts for about 15%. Anaerobic metabolism is significantly increased when there is a high need for energy or oxygen supply is reduced. Reduced coenzyme I (NADH) is an important coenzyme in the energy metabolism of glycolytic systems. To explore its distribution density is an important means to study brain metabolism. NADH has a unique fluorescence, according to the density of its distribution of experimental animals, fetal examination, neonatal behavior and severe asphyxia brain energy metabolism. Methods: 56 pregnant rabbits (weighing 32-65g) born from 11 pregnant females on the 28th to 31st day of pregnancy were tested within 2 days after birth. Among them, the heart rate above 140bpm do not give any load of freshmen