自由基促进的醇/醚α-O-C(sp3)-H键选择性活化的最新研究进展

• 作 者: 尚筱洁 柳忠全
• 机 构: 甘肃农业大学资源与环境学院,兰州大学功能有机分子化学国家重点实验室化学化工学院,
• 出 处: 化学学报
• 发表日期: 2015年12期
• 关键词: free radical alcohol C-H activation C-C bond formation oxidative coupling

醇/醚是最常见的化工原料,而醇羟基被认为是合成化学中的“万能”官能团转化基团.选择性地切断醇/醚分子中α-氧原子位的C(sp~3)—H键,构筑新的化学键,无疑是一种十分有吸引力的合成策略.近年来,一些很高效的经自由基历程的这类转化被相继报道.醇/醚作为起始原料,羟基的有效保留以及专一的区域选择性等优点使得此类合成方法备受关注.概述了近年来经自由基促进的脂肪醇及醚α-氧C(sp~3)—H键选择性活化构建C—C键的最新研究进展.

Alcohol / ether is the most common chemical raw material, and alcoholic hydroxyl group is considered as a “universal” functional group in synthetic chemistry.Selectively cutting C (sp ~ 3 ) -H bond, to build a new chemical bond, is undoubtedly a very attractive synthetic strategy.In recent years, some very efficient free radical course of this type of conversion have been reported.Other / ether as a starting material, hydroxyl And the special regioselectivity of this kind of synthetic methods have attracted much attention.It is summarized that the selective activation of free fatty alcohol and ether α-oxygen C (sp ~ 3) -H bond in recent years Recent Research Progress of C-C Bonds.