Synthesis and acaricidal activity of strobilurin-pyrimidine derivatives

• 作 者: Bao-Shan Chai Chang-Ling Liu Hui-Chao Li Shao-Wu Liu Ying Xu Yu-Quan Song Jun-Biao Chang
• 机 构: College of Chemistry and Molecular Engineering,Zhengzhou University,State Key Laboratory of the Disc
• 出 处: Chinese Chemical Letters
• 发表日期: 2014年01期
• 关键词: pyrimidine Tetranychus greenhouse screening bioactivity fluorine introducing sub

Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by1H NMR, MS and elemental analysis. Preliminary bioassays demonstrated that compounds 7e and 7i exhibited significant control against Tetranychus cinnabarinus(Boisd.) at 0.625 mg L 1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse. The relationship between structure and acaricidal activity was also studied.

Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because of the incorporation of fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by 1H NMR, MS and elemental analysis. The relationship between structure and acaricidal activity was also studied. In this bioassay the compounds 7e and 7i represent significant control against Tetranychus cinnabarinus (Boisd.) At 0.625 mg L 1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse.