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Pancreaticoduodenal artery pseudoaneurysm is one kind of rare splanchnic artery aneurysm.Hemorrhage from the lesion could be life-threatening.We present a case which color Doppler ultrasound and computed tomography angiography (CTA) only showed pancreatic pseudocyst on the background of chronic pancreatitis at first,but contrast-enhanced ultrasound detected blood flow in the pseudocyst and a pancreaticoduodenal artery pseudoaneurysm was worked up several days after.Finally,the pancreaticoduodenal artery pseudoaneurysm was confirmed by digital subtracted angiography.It might suggest the potential advantage of contrast-enhanced ultrasound in evaluating this kind of disease in comparison of CTA.