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本文报道氯苯甲噻二嗪治疗原发性肺动脉高压的临床经验。在治疗前,先测定氯苯甲噻二嗪注入肺动脉的效应。在测量肺动脉压、体循环动脉压和心排出量的基础值后,于肺动脉内快速注入45毫克氯苯甲噻二嗪。在脉率和血压稳定后(通常需5分钟)重复测定肺动脉压、体循环动脉压和心排出量,并测定血清氯苯甲噻二嗪浓度。然后相继于注射90、180和300毫克本药后再复测。效应良好的病人给予口服本药,剂量为每天400～600毫克,维持
This article reports the clinical experience of chlorbenzothiadiazide in the treatment of primary pulmonary hypertension. Prior to treatment, the effect of chlorbenzothiadiazide injection into the pulmonary artery was measured. After measuring the basal values of pulmonary arterial pressure, systemic arterial pressure and cardiac output, 45 mg of chlorbenzidine was rapidly injected into the pulmonary artery. Pulmonary arterial pressure, systemic arterial pressure and cardiac output were measured repeatedly after the pulse rate and blood pressure were stabilized (usually for 5 minutes), and the serum chlorbenzidine concentration was measured. Then one after the injection of 90,180 and 300 mg of the drug and then retest. Good effect of oral administration of the drug to patients, the dose of 400 to 600 mg per day, to maintain