长春花地上部分单吲哚类生物碱成分研究

• 作 者: 钟祥章 王国才 王英 张晓琦 叶文才
• 机 构: 中国药科大学天然药物化学教研室,暨南大学中药药效物质基础及创新药物研究广东省高校重点实验室,暨南大学中药及天然药物研究所,
• 出 处: 药学学报
• 发表日期: 2010年04期
• 关键词: 吲哚类生物碱 长春花属 夹竹桃科 清热平肝 Apocynaceae 柱色谱 分离纯化 醇提取物 化学结构 roseus

长春花Catharanthus roseus(L.)G.Don为夹竹桃科(Apocynaceae)长春花属(Catharanthus)植物,具有解毒抗癌、清热平肝等功效。为进一步研究其生物碱类活性成分,对其地上部分95%乙醇提取物采用硅胶正相柱色谱及制备高效液相色谱进行了分离纯化,共得到6个单吲哚类生物碱。根据理化性质和波谱数据鉴定了它们的化学结构,分别为vindolinine B(1)、洛柯碱(2)、荷哈默辛碱(3)、文多尼定碱(4)、文多灵(5)和狗牙花定碱(6)。其中化合物1为新化合物,命名为vindolinine B。

Catharanthus roseus (L.) G.Don is a plant belonging to the genus Catharanthus of the Apocynaceae family and has the functions of detoxification and anti-cancer and clearing heat and flattening the liver. In order to further study the alkaloid active ingredients, 95% ethanolic extracts of the aboveground parts were isolated and purified by silica gel normal phase column chromatography and preparative high performance liquid chromatography. Six single indole alkaloids were obtained. Their chemical structures were identified on the basis of physico-chemical properties and spectral data, and were identified as vindolinine B (1), rococo (2), hexhamin (3), venomidine (4) 5) and berberine (6). Among them, compound 1 is a new compound named vindolinine B.