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Long-term natural and human selections have domesticated crops from their wild progenitors for millennia, leading to the fixation of a large number of agronomically beneficial alleles and traits in cultivated crops.However, this process has been extremely time-consuming, accompanied with negative consequences, such as genetic erosion, accumulation of deleterious mutations and decreased environmental adaptation.Global population increase and climate change are increasingly threatening food security.One potential solution to this problem is the use of genome editing for rapid domestication of novel crops [1].Pioneers in this field have managed to de novo domesticate wild tomatoes and groundcherry [2,3].In a recent issue of Cell, Li's group from the Chinese Academy of Sciences and collaborators provided an exciting illustration of de novo domestication of a wild allotetraploid rice [4].